2014년도 2학기 신경과학
제출일자 11월 26일
Every week Q& A (25)
1 . Outline things involved in the presynaptic release of neurotransmitter. How come would the closure of your potassium route in the presynaptic axon airport terminal change the amount of Ca2︎ entering and change the amount of neurotransmitter released? Serotonin(5-HT) receptor within the sensory axon terminals can be described as G-protein-coupled metabotropic receptor. Activation of this receptor leads to the production of intracellular second messengers, cAMP, which will activates necessary protein kinase A. This chemical phosphorylates different proteins, between which a potassium route. Since potassium channel can be closed by simply phosphorylation, the presynaptic actions potential is elongated, leading to more Ca2 entry through voltage-gated calcium channels through the action potential. More quanta of neurotransmitter are produced because of this series of action.
2 . Rabbits can be classically trained to blink reacting to a tone. This is accomplished by repeatedly pairing the tone with a great air use the e-cig to the eye. Richard Thompson and his co-workers at Stanford University make the following observations: Learning fails to occur, as well as the memory can be wiped out, in the event the cerebellum is usually surgically removed; the air use the e-cig activates skin cells in the substandard olive; the tone stimulates cerebellar mossy fibers. Utilizing your knowledge of synaptic plasticity in the cerebellum, offer a mechanism for time-honored conditioning inside the rabbit. In this setting, the CS is actually a tone plus the US is the air puff to the attention of a bunny. In classical conditioning, the subject(rabbit) learns that the CS predicts the united states. Here, the CS initiates cerebellar mossy fibers, which in turn synapses on cerebellar granule cells. Cerebellar granule skin cells give rise to axons that department as a seite an seite fiber. The US activates cellular in the poor olive, which in turn integrates details from muscle mass proprioceptor and projects the axons, hiking fibers, towards the Purkinje skin cells. The convergence of parallel and...
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